Adoptive Cell Therapy

astases with Adoptive Cell Therapy

ownloade pose: To determine the objective response rate and response duration of melanoma brain metaso adoptive cell therapy (ACT) with autologous antitumor lymphocytes plus interleukin-2 following phodepleting preparative regimen. hods: Between 2000 and 2009, 264 patients with metastatic melanoma received ACT, consisting of hosphamide and fludarabine with or without total body irradiation, fol...

Principles of adoptive T cell cancer therapy.

The transfusion of T cells, also called adoptive T cell therapy, is an effective treatment for viral infections and has induced regression of cancer in early-stage clinical trials. However, recent advances in cellular immunology and tumor biology are guiding new approaches to adoptive T cell therapy. For example, use of engineered T cells is being tested as a strategy to improve the functions o...

Adoptive T-cell therapy for malignant disorders.

Adoptive T-Cell Therapy for Cancer.

Recent developments have demonstrated that immunotherapies are capable of achieving durable antitumor responses in patients with metastatic cancer. One modality that has been able to induce durable complete regressions in patients with melanoma has been adoptive cell therapy (ACT). This has slowly been expanded to other cancer types using new approaches such as genetically engineered T-cells an...

Adoptive T-cell therapy of cancer.

Adoptive therapy involves the transfer of ex vivo expanded immune effector cells to patients as a means of augmenting the antitumor immune response. In general, this transfer is accomplished by harvesting cells from the peripheral blood, tumor sites, or draining lymph nodes and expanding effector cells in a specific or nonspecific fashion for adoptive transfer. This article describes the ration...